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Founding Scientist Synthetic Genomics

San Francisco,...
E

Exonic

Startup
Category
Technical
Experience
0-3 years
Type
Full-Time
Location
San Francisco, CA, US
Salary
$120,000 - $180,000
Job Description
Benefits & Culture
Equity compensation
Core Values
Ownership
Execution speed
Comfort with ambiguity
This goes straight to the founder
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Founder Signals
Response Rate
85%
Avg Response Time
2 hours
Compensation Calculator
In startups, higher salary usually means lower equity.
Salary (affects equity %)
Link salary ↔ equity
$125,000
$120,000$180,000
Equity % (auto from trade-off model)
1.13%
0%5%
Projected Exit Value
$350,000,000
$10M$500M
Live Trade-off
Salary
Equity %
Est. Equity Value at Exit
$100,000
1.19%
$2,082,500
$125,000
1.13%
$1,983,333
$150,000
0.85%
$1,487,500
$175,000
0.57%
$991,667

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Company Overview

Exonic Biosciences · Dogpatch, San Francisco

Exonic is building AI systems for programmable biology. We train multimodal foundation models on large-scale biological datasets to design synthetic non-coding DNA. We experimentally validate our AI-designed systems in mammalian cells, with current applications in cell-type targeting and viral vector biomanufacturing. Our core focus is synthetic regulatory DNA. We have already generated strong in vitro cell-type targeting results and are expanding our internal experimental platform in San Francisco.

Role Overview

We are looking for an ambitious experimental scientist to take ownership of Exonic’s wet-lab work and help push the platform into new directions. You would work directly with the founder as one of the first people in the company.

Responsibilities

  1. Own and execute experimental validation of AI-designed regulatory DNA
  2. Design and run cell-based assays for synthetic enhancer and expression systems
  3. Help advance programs in cell-type targeting and AAV manufacturing
  4. Help shape Exonic’s experimental roadmap as the company grows

Relevant experience

  1. Molecular biology, synthetic biology, regulatory genomics, or gene therapy
  2. Mammalian cell culture and cell-based assays
  3. Cloning, plasmid design, transfection, qPCR/ddPCR, sequencing, flow, luciferase, or related workflows
  4. AAV biology/manufacturing experience is a major plus

We care most about ownership, execution speed, and comfort with ambiguity. This is an early-stage role with autonomy, and the opportunity to build the biological engine of an AI-native synthetic DNA company.

Location: San Francisco / MBC BioLabs